restorative effect of vitamin e on some immunological parameters of sub-lethal γ-irradiated balb/c mice

Authors

سوسن کبودیان اردستانی

sussan k. ardestani مجتبی امانی

mogtaba amani آمینا کریمی نیا

amina kariminia

abstract

elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. therefore, we made attempts to investigate the protective effect of vitamin e (vit-e), a biological antioxidant in balb/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. several groups of mice were selected and exposed to sub-lethal g -irradiation with or without vit-e supplementation. at the end of exposure, mice were immunized by either live attenuated brucellamelitensis vaccine or sheep red blood cell (srbc). consequently, the following parameters were assayed: specific antibody response, delayed type hypersensitivity and lymphocyte proliferation. we showed that vit-e supplementation restored the immune response in g -irradiated mice. these findings might have implications for individuals who are at risk of exposure to ionizing radiation.

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Journal title:
iranian biomedical journal

جلد ۴، شماره ۱، صفحات ۵۱-۵۵

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